B Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis

Signaling Regulation of B Cell Homeostasis B Cell Receptor and BAFF Receptor

Terminating B cell receptor signaling

Bruton’s tyrosine kinase (BTK) mediated signaling is critical for B cell development and activation. The physiological role of BTK is evident since its functional loss results in a differentiation block of B cells beyond the pro-B cell stage causing X-linked agammaglobulinemia. Inhibitors of BTK, such as ibrutinib and acalabrutinib profoundly impair BCR signaling. They are highly effective in t...

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

Follicular B cell survival requires signaling from BAFFR, a receptor for BAFF and the B cell antigen receptor (BCR). This "tonic" BCR survival signal is distinct from that induced by antigen binding and may be ligand-independent. We show that inducible inactivation of the Syk tyrosine kinase, a key signal transducer from the BCR following antigen binding, resulted in the death of most follicula...

Signaling in B Cells Regulation of TLR and B Cell Receptor Bone Marrow Dendritic Cell-Mediated

Absence of mature peripheral B cell populations in mice with concomitant defects in B cell receptor and BAFF-R signaling.

Generation of mature B lymphocytes from early (T1) and late transitional (T2) precursors requires cooperative signaling through BCR and B cell-activating factor receptor 3 (BR3). Recent studies have shown that BCR signaling positively regulates NF-kappaB2, suggesting BCR regulation of BR3 signaling. To investigate the significance of signal integration from BCR and BR3 in B cell development and...